This passage records two more examples of Jesus’ supernatural power over disease. He healed two conditions, leprosy and paralysis, whose cure was far beyond the limited medical knowledge of that day. But, these healings do more than reveal Jesus’ divine power and compassion. The story of His healing the leper provides an analogy of the penitent sinner’s approach to Him, and the account of His healing the paralyzed man contains the revelation of His authority to forgive sin.
From: The MacArthur New Testament Commentary: Luke 1-5 by John MacArthur (Chicago: Moody Press, 2009), p. 312. Comment on Luke 5:12-26.